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Determination of the Inhibitory Activity of Ferula sinkiangensis Polysaccharides for Protein Tyrosine Phosphatase 1B

  • S. Wulamu
  • H. Yimamu
  • A. Abuduwaili
  • P. Mutailifu
  • V. V. Maksimov
  • Y. H. Gao
  • A. YiliEmail author
  • H. A. Aisa
Article
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Polysaccharide fractions were sequentially extracted in 28.86 wt% yield from roots of Ferula sinkiangensis K. M. Shen. The polysaccharide fractions from F. sinkiangensis were identified as heteropolysaccharides and contained primarily the monosaccharides glucuronic and galacturonic acids, rhamnose, xylose, arabinose, galactose, and fructose. The isolated polysaccharide fractions at low concentrations exhibited in vitro inhibitory activity for protein-tyrosine phosphatase 1B. The degree of inhibition correlated with the galactose content in the polysaccharide fractions.

Keywords

Ferula sinkiangensis K. M. Shen polysaccharides HPTLC protein-tyrosine phosphatase 1B (PTP1B) inhibitor 

Notes

Acknowledgment

The research was financially supported by the Major Special Project of National Science and Technology, Research and Development of New Ethnic Drug Varieties and Its Key Innovation Technology (2017ZX09301045) and Tianshan Excellence Project in 2017-47 in addition to the Central Asia Drug Research and Development Center of the Chinese Academy of Sciences.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • S. Wulamu
    • 1
    • 2
  • H. Yimamu
    • 3
  • A. Abuduwaili
    • 2
    • 4
  • P. Mutailifu
    • 2
    • 4
  • V. V. Maksimov
    • 5
  • Y. H. Gao
    • 4
    • 6
  • A. Yili
    • 4
    • 6
    Email author
  • H. A. Aisa
    • 4
    • 6
  1. 1.School of Life SciencesYili Normal UniversityXinjiangP. R. China
  2. 2.University of Chinese Academy of ScienceBeijingP. R. China
  3. 3.School of PharmacyXinjiang Medical UniversityUrumqiP. R. China
  4. 4.State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqiP. R. China
  5. 5.A. S. Sadykov Institute of Bioorganic ChemistryAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan
  6. 6.Key Laboratory of Plants Resources and Chemistry of Arid Zone, Xinjiang Technical Institute of Physics and ChemistryChinese Academy of SciencesUrumqiP. R. China

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