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Chemistry of Natural Compounds

, Volume 54, Issue 5, pp 1020–1022 | Cite as

Isoquinoline Alkaloids from Corydalis pallida

  • Ah-Reum Han
  • Hyang Rim Kim
  • Yun Seo Kil
  • Unwoo Kang
  • Dae Sik Jang
  • Eun Kyoung Seo
Article

Corydalis pallida (Thunb.) Pers. (Papaveraceae) has been used as a traditional medicine for removing fever, toxins, and edema in Southeast Asia [1]. There have not been many researches on the single species of C. pallida, although some alkaloids have been isolated from C. pallida [2], mixtures of C. pallida and C. montana [3], mixtures of C. pallida and C. aurea [4], or mixtures of C. pallida and C. bulbosa [5]. Several Corydalis plants were reported to have diverse biological activities such as chemopreventive [6], antitumor [2, 6–8], gastrointestinal motility inducing [9], anti-inflammatory [10], and anti-allergic [11] activities from the major constituents, isoquinoline alkaloids.

As part of our ongoing research to find bioactive compounds from traditional herbal medicines [2], phytochemical investigations on the ethyl acetate extract of the whole plants of C. pallida resulted in the isolation of six known protoberberine alkaloids, (–)-corydalidzine (1) [12–14], (–)-corybulbine (2)...

Notes

Acknowledgment

This work was supported in part by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MSIP) (No. 2013R1A2A2A01067336).

References

  1. 1.
    M. K. Sin, C. M. Kim, D. K. Ahn, and K. S. Lee, Dictionary of Chinese Materia Medica (Student Edition), Jungdam Publishing, Seoul, Korea, 1997, 495 pp.Google Scholar
  2. 2.
    H. R. Kim, H.-Y. Min, Y. H. Jeong, S. K. Lee, N. S. Lee, and E.-K. Seo, Arch. Pharm. Res., 28, 1224 (2005).Google Scholar
  3. 3.
    R. H. F. Manske, J. Am. Chem. Soc., 69, 1800 (1947).Google Scholar
  4. 4.
    R. H. F. Manske, Can. J. Res. B, 18, 80 (1940).Google Scholar
  5. 5.
    C. Ito, M. Itoigawa, H. Tokuda, M. Kuchide, H. Nishino, and H. Furukawa, Planta Med., 67, 473 (2001).Google Scholar
  6. 6.
    J.-L. Gao, J.-M. Shi, S. M.-Y. Lee, Q.-W. Zhang, and Y.-T. Wang, Oncol. Res., 17, 519 (2009).Google Scholar
  7. 7.
    Y. Lei, J. Tan, M. Wink, Y. Ma, N. Li, and G. Su, Food Chem., 136, 1117 (2013).Google Scholar
  8. 8.
    Z. Xu, X. Chen, S. Fu, J. Bao, Y. Dang, M. Huang, L. Chen, and Y. Wang, Am. J. Chin. Med., 40, 177 (2012).Google Scholar
  9. 9.
    T. H. Lee, K. H. Kim, S. O. Lee, K. R. Lee, M. Son, and M. Jin, J. Pharmacol. Exp. Ther., 338, 917 (2011).Google Scholar
  10. 10.
    M. Kubo, H. Matsuda, K. Tokuoka, S. Ma, and H. Shiomoto, Biol. Pharm. Bull., 17, 262 (1994).Google Scholar
  11. 11.
    S. Saito, M. Tanaka, K. Matsunaga, Y. Li, and Y. Ohizumi, Biol. Pharm. Bull., 27, 1270 (2004).Google Scholar
  12. 12.
    J. Slavik and L. Slavikova, Collect. Czech. Chem. C, 54, 2009 (1989).Google Scholar
  13. 13.
    C. Tani, N. Nagakura, and S. Hattori, Chem. Pharm. Bull., 23, 313 (1975).Google Scholar
  14. 14.
    B. Sener and H. Temizer, J. Chem. Soc. Pakistan, 13, 63 (1991).Google Scholar
  15. 15.
    H. Kaneko and S. Naruto, J. Org. Chem., 34, 2803 (1969).Google Scholar
  16. 16.
    T. Kametani, M. Ihara, and T. Honda, J. Chem. Soc. C, 8, 1060 (1970).Google Scholar
  17. 17.
    K. Iwasa, M. Sugiura, and N. Takao, J. Org. Chem., 47, 4275 (1982).Google Scholar
  18. 18.
    S. Tong, J. Yan, and J. Lou, J. Liq. Chromatogr. R. T., 28, 2979 (2005).Google Scholar
  19. 19.
    J. Dostal, S. Man, P. Seckarova, D. Hulova, M. Necas, M. Potacek, J. Tousek, R. Dommisse, W. Van Dongen, and R. Marek, J. Mol. Struct., 687, 135 (2004).Google Scholar
  20. 20.
    Y.-R. Wu, Y.-B. Ma, Y.-X. Zhao, S.-Y. Yao, J. Zhou, Y. Zhou, and J.-J. Chen, Planta Med., 73, 787 (2007).Google Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ah-Reum Han
    • 1
    • 2
  • Hyang Rim Kim
    • 1
  • Yun Seo Kil
    • 1
  • Unwoo Kang
    • 1
  • Dae Sik Jang
    • 3
  • Eun Kyoung Seo
    • 1
  1. 1.College of Pharmacy, Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulKorea
  2. 2.Advanced Radiation Technology Institute, Korea Atomic Energy Research InstituteJeongeupKorea
  3. 3.Department of Pharmaceutical Science, College of PharmacyKyung Hee UniversitySeoulKorea

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