Chemistry of Natural Compounds

, Volume 54, Issue 5, pp 1020–1022 | Cite as

Isoquinoline Alkaloids from Corydalis pallida

  • Ah-Reum Han
  • Hyang Rim Kim
  • Yun Seo Kil
  • Unwoo Kang
  • Dae Sik Jang
  • Eun Kyoung SeoEmail author

Corydalis pallida (Thunb.) Pers. (Papaveraceae) has been used as a traditional medicine for removing fever, toxins, and edema in Southeast Asia [1]. There have not been many researches on the single species of C. pallida, although some alkaloids have been isolated from C. pallida [2], mixtures of C. pallida and C. montana [3], mixtures of C. pallida and C. aurea [4], or mixtures of C. pallida and C. bulbosa [5]. Several Corydalis plants were reported to have diverse biological activities such as chemopreventive [6], antitumor [2, 6–8], gastrointestinal motility inducing [9], anti-inflammatory [10], and anti-allergic [11] activities from the major constituents, isoquinoline alkaloids.

As part of our ongoing research to find bioactive compounds from traditional herbal medicines [2], phytochemical investigations on the ethyl acetate extract of the whole plants of C. pallida resulted in the isolation of six known protoberberine alkaloids, (–)-corydalidzine (1) [12–14], (–)-corybulbine (2)...



This work was supported in part by the National Research Foundation of Korea (NRF) Grant funded by the Korea Government (MSIP) (No. 2013R1A2A2A01067336).


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Ah-Reum Han
    • 1
    • 2
  • Hyang Rim Kim
    • 1
  • Yun Seo Kil
    • 1
  • Unwoo Kang
    • 1
  • Dae Sik Jang
    • 3
  • Eun Kyoung Seo
    • 1
    Email author
  1. 1.College of Pharmacy, Graduate School of Pharmaceutical SciencesEwha Womans UniversitySeoulKorea
  2. 2.Advanced Radiation Technology Institute, Korea Atomic Energy Research InstituteJeongeupKorea
  3. 3.Department of Pharmaceutical Science, College of PharmacyKyung Hee UniversitySeoulKorea

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