Chemistry of Natural Compounds

, Volume 54, Issue 5, pp 864–868 | Cite as

Synthesis and Anticoagulant Bioactivity of Heterocyclic Derivatives of Resveratrol

  • H. J. Yang
  • Y. J. RenEmail author
  • C. Du
  • L. Jin
  • R. Li
  • N. Xie

Twenty-five resveratrol derivatives were synthesized, among which eight compounds have not yet been reported. The target compounds were evaluated for thrombin inhibitory activity in vitro (IC50). The results showed that four compounds displayed a better thrombin inhibitory activity with IC50 values from 10.43 to 18.31 μM, better than resveratrol (25.87 μM). The R3 position of resveratrol was modified by heterocyclic rings containing oxygen and sulfur, which could increase the anticoagulant activity of resveratrol.


resveratrol lipophilic derivatives heterocyclic rings anticoagulant activity thrombin 



This work is financed by Shanghai College Students Innovative Projects (Nos. SH2016016 and SH2016018).


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© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • H. J. Yang
    • 1
  • Y. J. Ren
    • 1
    • 2
    Email author
  • C. Du
    • 1
  • L. Jin
    • 1
  • R. Li
    • 1
  • N. Xie
    • 1
  1. 1.College of Chemical and Environmental EngineeringShanghai Institute of TechnologyShanghaiP. R. China
  2. 2.Key Laboratory of Synthetic Chemistry of Natural Substances, Shanghai Institute of Organic ChemistryChinese Academy of SciencesShanghaiP. R. China

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