Absolute Configuration of (2R,3R,6S,8R)-Methyl Homononactate, a Polyketide from Actinomycetes Streptomyces sp. R-527F of the Arctic Region
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Since the first report of the discovery and separation of microbes by Ekelof in the Antarctic region in 1908, the microbiological, ecological, and chemical studies of the strains from polar regions have become a hotspot due to the special living environments of the microorganisms, such as extremely low temperature, high salinity, and intense radiation [1, 2]. Diverse natural products, such as terpenoids, alkaloids, and polyketides, with a wide range of biological activities, including cytotoxicity, antiviral activity, etc., were found from microbes of the polar regions [3, 4]. Among them, macrotetrolide type polyketides have attracted a lot of attention thanks to their high chemical complexity and biological diversity [5, 6, 7]. In fact, macrotetrolides are a family of cyclic polyethers biosynthetically derived from several molecules of enantiomeric nonactic acid or its homologs with a (+)(–)(+)(–)-ester connection, an intriguing molecular topology seldom observed in other natural...
This research work was financially supported by the Natural Science Foundation of China (Nos. 81520108028, 81273430, 41306130, 81302692, 41676073, 81603022), SCTSM Project (Nos. 14431901100, 15431901000), Institutes for Drug Discovery and Development, Chinese Academy of Sciences (No. CASIMM0120152039), and the SKLDR/SIMM Projects (SIMM 1501ZZ-03). X.-W. Li acknowledges the financial support of the “Youth Innovation Promotion Association” (Grant No. 2016258) from the Chinese Academy of Sciences, the “Young Talent Supporting Project” from the China Association for Science and Technology, and the Shanghai “Pujiang Program.” F. Ye acknowledges the financial support of the Syngenta-SIMM-PhD Studentship Project.
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