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Chemistry of Natural Compounds

, Volume 54, Issue 3, pp 450–454 | Cite as

Induced Production of Furan Derivatives in a Fungal Endophyte Ceriporia lacerate HS-ZJUT-C13A by the Osmac Method

  • Hang-Fei Yu
  • Fang-Jun Qiu
  • Yue-Jun Wang
  • Yuan-Yuan Li
  • Ling Fang
  • Jian-Biao Yao
  • Zha-Jun Zhan
  • Wei-Guang Shan
  • You-Min Ying
Article
  • 34 Downloads

The One Strain Many Compounds (OSMAC) method was employed to explore the chemical diversities of secondary metabolites produced by Ceriporia lacerate HS-ZJUT-C13A, a fungal endophyte of Huperzia serrata. Four new furan derivatives 1–4, together with a known compound, were obtained from the rice culture of the fungus. The structures of the new compounds were established by detailed analysis of the spectroscopic data, especially 1D and 2D NMR, and HR-ESI-MS. All compounds were evaluated for their acetylcholinesterase inhibitory activity and antiproliferative activities against HeLa, HepG2, and SGC7901 cell lines.

Keywords

fungal endophyte Huperzia serrata secondary metabolites OSMAC Ceriporia 

Notes

Acknowledgment

This work was financially supported by the National Natural Science Foundation of China (No. 21402174) and the Natural Science Foundation of Zhejiang Province (LY17B020011).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Hang-Fei Yu
    • 1
  • Fang-Jun Qiu
    • 2
  • Yue-Jun Wang
    • 2
  • Yuan-Yuan Li
    • 3
    • 4
  • Ling Fang
    • 4
  • Jian-Biao Yao
    • 4
  • Zha-Jun Zhan
    • 1
  • Wei-Guang Shan
    • 1
  • You-Min Ying
    • 1
    • 2
    • 4
  1. 1.College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhouP. R. China
  2. 2.Zhejiang Xinguang Pharmaceutical Limited Liability CompanyShaoxingP. R. China
  3. 3.Hangzhou Medical CollegeHangzhouP. R. China
  4. 4.Zhejiang Key Laboratory of Traditional Chinese Medicine Pharmaceutical Technology, Zhejiang CONBA Pharmaceutical Co., Ltd.HangzhouP. R. China

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