Chemistry of Natural Compounds

, Volume 54, Issue 2, pp 310–314 | Cite as

Synthesis and Biological Activity of Several Modified 5α-Androstanolone Derivatives

  • N. Sh. Nadaraia
  • N. N. Barbakadze
  • M. L. Kakhabrishvili
  • B. Sylla
  • A. Pichette
  • U. S. Makhmudov
Article
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Several new N-containing epiandrosterone derivatives modified by phenylacetic acid chloride were synthesized for biological activity studies. Compounds with antiviral activity were discovered among them and 3β-hydroxy-1′-aryl-3′-methyl-5′-androstano[17,16-d]pyrazolines prepared by us earlier.

Keywords

antiviral activity epiandrosterone modification phenylacetic acid hydrazones pyrazolines 

Notes

Acknowledgment

The work was financially supported by the Shota Rustaveli National Science Foundation of Georgia (Grant No. YS-2016-51, Potential Bioactive Steroidal Nitrogen-containing Compounds).

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • N. Sh. Nadaraia
    • 1
  • N. N. Barbakadze
    • 1
  • M. L. Kakhabrishvili
    • 1
  • B. Sylla
    • 2
  • A. Pichette
    • 2
  • U. S. Makhmudov
    • 3
  1. 1.I. Kutateladze Institute of PharmacochemistryTbilisi State Medical UniversityTbilisiGeorgia
  2. 2.LASEVE, Universite Quebec a ChicoutimiChicoutimiCanada
  3. 3.S. Yu. Yunusov Institute of the Chemistry of Plant SubstancesAcademy of Sciences of the Republic of UzbekistanTashkentUzbekistan

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