Addition of Cyanoethyl Groups to Ring a of Triterpenoids
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The potential for cyanoethylation of ring A of triterpenoids and their A-seco derivatives prepared from allobetulone and methyl betulonate was investigated. Triterpenoids with a cyanoethyl moiety on C-1, C-2, and C-3 and derivatives with two cyanoethyl groups on ring A were synthesized. The inhibitory activity of the synthesized compounds for herpes simplex virus type 1 was studied in vitro.
Keywordstriterpenoids A-seco-triterpenoids betulin cyanoethylation acrylonitrile antiviral activity herpes simplex virus type 1
The work was financially supported by the Government of Perm Krai in the framework of Science Project No. C-26/056, grants MK-5386.2016.3, RFBR No. 16-53-00029Bel_a and BRFBR No. M16R-012.
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