Anti-Tobacco Mosaic Virus Isocoumarins from the Fermentation Products of the Endophytic Fungus Aspergillus versicolor
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Two new isocoumarins, (3R)-methyl-8-hydroxy-6-(hydroxymethyl)-7-methoxydihydroisocoumarin (1) and (3R)-methyl-7,8-dimethoxy-6-(hydroxymethyl)dihydroisocoumarin (2), together with three known isocoumarins (3–5), were isolated from the fermentation products of an endophytic fungus Aspergillus versicolor. Their structures were elucidated by spectroscopic methods, including extensive 1D and 2D NMR techniques. The anti-tobacco mosaic virus (anti-TMV) activities of compounds 1 and 2 were evaluated. Compounds 1 and 2 showed anti-TMV activities with inhibition rates of 21.8 and 18.6% at the concentration of 20 μM, respectively.
Keywordsisocoumarins fermentation products Aspergillus versicolor anti-tobacco mosaic virus activities
This research was financially supported by the National Natural Science Foundation of China (Nos. 21462051 and 31560099), the Foundation of Yunnan Province (No. 2015BA006 and Category of Industry Guide No. 2014-01), the Foundation of China Tobacco Yunnan Industrial Co., Ltd. (2015539200340277), and the Foundation of China National Tobacco Corporation (110201402040).
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