Two New Benzolactones from the Leaves of Yunnan Local Sun Cured Tobacco and Their Bioactivities
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Two new benzolactones, 4-methoxy-6-(2-oxopropyl)isobenzofuran-1(3H)-one (1) and 4-methyl-6-(2-oxopropyl)isobenzofuran-1(3H)-one (2), were isolated from the leaves of Yunnan local sun cured tobacco. Their structures were determined by means of HR-ESI-MS and extensive 1D and 2D NMR spectroscopic studies. Compounds 1 and 2 were tested for their anti-tobacoo mosaic virus (TMV) activities and cytotoxicity activities. The results revealed that compounds 1 and 2 showed high anti-TMV activity with inhibition rates of 32.6 and 30.2%. These rates are close to that of positive control. Compounds 1 and 2 also showed weak inhibitory activities against some tested human tumor cell lines.
Keywordsbenzolactones Yunnan local sun cured tobacco anti-tobacco mosaic virus cytotoxicity activities
This research was supported by the National Natural Science Foundation of China (No. 31360081), the Applied Fundamental Foundation of Yunnan Province (No. 2013FB097), and the Basic Research Foundation of Yunnan Tobacco Industry Co. Ltd. (2013FL05 and 2012JC01).
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