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Chemistry of Natural Compounds

, Volume 53, Issue 5, pp 988–990 | Cite as

Lupane Triterpenoids and Sterols from Inonotus rheades Mycelium and their Anti-Glucosidase Activity

  • D. N. Olennikov
  • T. G. Gornostai
  • T. A. Penzina
  • G. B. Borovskii
Article

Extracts and pure compounds from Inonotus obliquus are known to possess hypoglycemic activity due to inhibitory effects on several digestive enzymes in addition to antioxidant [1] and reparative action on pancreatic β-cells [2]. Previously, we found that extracts of I. rheades mycelium possessed antioxidant activity [3] due to the presence of phenolic compounds, in particular, styrylpyrones and bis(styrylpyrones) [4]. Studies of the biological activity of constituents from I. rheades mycelium established inhibitory activity of the plant extracts on several digestive enzymes. In particular, the 50% inhibition concentration for α-glucosidase activity (IC50) of hexane fraction Ir-01 was 56.40 μg/mL [4], which prompted detailed studies of it.

In order to determine the active compounds, fraction Ir-01 (0.5 g) was separated by column chromatography (CC) over silica gel (3 × 30 cm, hexane–EtOAc, 100:0→70:30) to produce subfractions Ir-01/1–Ir-01/7. Then, subfraction Ir-01/2 was...

Notes

Acknowledgment

The work was supported financially by the RFBR No. 16-43-030857.

References

  1. 1.
    J. E. Sun, Z. H. Ao, Z. M. Lu, H. Y. Xu, X. M. Zhang, W. F. Dou, and Z. H. Xu, J. Ethnopharmacol., 118, 7 (2008).CrossRefPubMedGoogle Scholar
  2. 2.
    B. Diao, W. Jin, and X. Yu, Evidence Based Complementary Altern. Med., 2014, Art. ID 841496 (2014).Google Scholar
  3. 3.
    T. G. Gornostay, T. A. Penzina, V. A. Chkhenkeli, M. S. Polyakova, S. N. Osipenko, G. B. Borovski, and D. N. Olennikov, Basic Clin. Pharm. Toxicol., 115, 10 (2014).Google Scholar
  4. 4.
    D. N. Olennikov, T. G. Gornostai, and T. A. Penzina, Chem. Nat. Compd.,53, 629 (2017).CrossRefGoogle Scholar
  5. 5.
    D. Du, F. Zhu, X. Chen, X. Ju, Y. Feng, L. W. Qi, and J. Jiang, Phytochem. Anal., 22, 419 (2011).CrossRefPubMedGoogle Scholar
  6. 6.
    J. R. Dias and H. Gao, Spectrochim. Acta, Part A, 74, 1064 (2009).Google Scholar
  7. 7.
    D. S. Kim, N. Baek, S. R. Oh, K. Y. Jung, I. S. Lee, J. H. Kim, and H. Lee, Arch. Pharm. Res., 20, 201 (1997).CrossRefPubMedGoogle Scholar
  8. 8.
    S. Mouffok, H. Haba, C. Lavaud, C. Long, and M. Benkhaled, Rec. Nat. Prod., 6, 292 (2012).Google Scholar
  9. 9.
    R. Ferreira, H. Garcia, A. F. Sousa, C. S. R. Freire, A. J. D. Silvestre, W. Kunz, L. P. N. Rebelo, and C. S. Pereira, RSC Adv., 3, 21285 (2013).CrossRefGoogle Scholar
  10. 10.
    E. Bisoli, W. S. Garcez, L. Hamerski, C. Tieppo, and F. R. Garcez, Molecules, 13, 2717 (2008).CrossRefPubMedGoogle Scholar
  11. 11.
    M. Liu, S. Yang, L. Jin, D. Hu, Z. Wu, and S. Yang, Molecules, 17, 6156 (2012).CrossRefPubMedGoogle Scholar
  12. 12.
    N. Melnikova, I. Burlov, T. Kiseleva, I. Klabukova, M. Gulenova, A. Kislitsin, V. Vasin, and B. Tanaseichuk, Molecules, 17, 11849 (2012).CrossRefPubMedGoogle Scholar
  13. 13.
    F. A. Macias, A. M. Simonet, and M. D. Esteban, Phytochemistry, 36, 1369 (1994).CrossRefGoogle Scholar
  14. 14.
    Y. Shin, Y. Tamai, and M. Terazawa, Eurasian J. For. Res., 1, 43 (2000).Google Scholar
  15. 15.
    Y. J. Kim, J. Park, B. S. Min, and S. H. Shim, J. Korean Soc. Appl. Biol. Chem., 54, 287 (2011).Google Scholar
  16. 16.
    J. H. Kang, J. E. Jang, S. K. Mishra, H. J. Lee, C. W. Nho, D. Shin, M. Jin, M. K. Kim, C. Choi, and S. H. Oh, J. Ethnopharmacol., 173, 303 (2015).CrossRefPubMedGoogle Scholar
  17. 17.
    K. Kahlos, L. Kangas, and R. Hiltunen, Planta Med., 55, 389 (1989).CrossRefPubMedGoogle Scholar
  18. 18.
    D. N. Olennikov and N. I. Kashchenko, Sci. World J., 2014, Art. ID 654193 (2014).Google Scholar

Copyright information

© Springer Science+Business Media, LLC 2017

Authors and Affiliations

  • D. N. Olennikov
    • 1
  • T. G. Gornostai
    • 2
  • T. A. Penzina
    • 3
  • G. B. Borovskii
    • 2
  1. 1.Institute of General and Experimental Biology, Siberian BranchRussian Academy of SciencesUlan-UdeRussia
  2. 2.Siberian Institute of Plant Physiology and Biochemistry, Siberian BranchRussian Academy of SciencesIrkutskRussia
  3. 3.Research Institute of BiologyIrkutsk State UniversityIrkutskRussia

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