Synthesis of Conjugates of Ursolic Acid 3-O-Succinate with NO-H2S Donors
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Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered to be promising agents for therapy of oncological diseases [ 1]. Herein, several conjugates of NSAIDs with the H 2S donor desmethyl anethole trithione [ 2] and NO donors, in particular nitro and furoxan derivatives [ 3], were prepared with the intent of optimizing the biological activity. Also, a series of ternary conjugates NOSH-NSAID were prepared. Their anti-inflammatory and cytotoxic activity was significantly greater than those of the starting NSAIDs [ 4, 5].
The work was sponsored by Project No. 12 of joint basic research of the NAS of Belarus and the SB RAS.
- 11.A. M. Gasco, D. Boschi, and A. Gasco, J. Heterocycl. Chem., 32, 811 (1995).Google Scholar
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