Chemistry of Natural Compounds

, Volume 53, Issue 3, pp 592–594 | Cite as

Synthesis of Conjugates of Ursolic Acid 3-O-Succinate with NO-H2S Donors

  • S. A. PopovEmail author
  • L. M. Kornaukhova
  • A. V. Shpatov
  • I. A. Grigor’ev
Nonsteroidal anti-inflammatory drugs (NSAIDs) are considered to be promising agents for therapy of oncological diseases [ 1]. Herein, several conjugates of NSAIDs with the H 2S donor desmethyl anethole trithione [ 2] and NO donors, in particular nitro and furoxan derivatives [ 3], were prepared with the intent of optimizing the biological activity. Also, a series of ternary conjugates NOSH-NSAID were prepared. Their anti-inflammatory and cytotoxic activity was significantly greater than those of the starting NSAIDs [ 4, 5].



The work was sponsored by Project No. 12 of joint basic research of the NAS of Belarus and the SB RAS.


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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • S. A. Popov
    • 1
    Email author
  • L. M. Kornaukhova
    • 1
  • A. V. Shpatov
    • 1
  • I. A. Grigor’ev
    • 1
  1. 1.Novosibirsk Institute of Organic ChemistryNovosibirskRussia

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