Influenza Antiviral Activity of Br-Containing [2R,4R(S),4aR,7R,8aR]-4,7-Dimethyl-2-(Thiophen-2-YL)Octahydro-2H-Chromen-4-Ols Prepared from (–)-Isopulegol
- 78 Downloads
Influenza A (H1N1) antiviral activity of compounds with an octahydro-2H-chromene skeleton that were prepared by reacting the monoterpenoid (–)-isopulegol and thiophenecarboxaldehyde and its derivatives was studied for the first time. The 5-bromothiophene-2-carboxaldehyde derivative exhibited the greatest antiviral activity.
Keywordsmonoterpenes thiophenecarboxaldehyde clay heterocyclic compounds antiviral activity influenza A
The research was supported financially by the Russian Science Foundation (Project No. 15-13-00017). We thank the Khimiya Center for Collective Use of the SB RAS for taking the spectral and analytical measurements.
- 1.Influenza (Seasonal) Fact Sheet No. 211, World Health Organization, Geneva, 2014; http://www.who.int/mediacentre/factsheets/fs211/en/
- 9.I. V. Il′ina, K. P. Volcho, D. V. Korchagina, N. F. Salakhutdinov, and V. A. Barkhash, Russ. J. Org. Chem., 35, 673 (1999).Google Scholar