Chemistry of Natural Compounds

, Volume 52, Issue 5, pp 969–970 | Cite as

Secondary Metabolites Isolated from the Sponge-Associated Fungus Nigrospora oryzae

  • Lijian Ding
  • Wei Yuan
  • Qi Peng
  • Huan Sun
  • Shihai Xu

Sponges represent one of the top-ranking sources of marine fungal diversity [1]. Many sponge-associated fungi are capable of producing structurally diverse and highly bioactive secondary metabolites [2]. Moreover, metabolites derived from sponge-associated fungi facilitate the development of sustainable products for the pharmaceutical, nutraceutical, and cosmetic industries [3]. Hence, we have paid ongoing attention to bioactive metabolites from sponge-associated fungi.

The fungus Nigrospora oryzae was isolated from the marine sponge Clathrina luteoculcitella collected off Yongxing Island in the South China Sea. Nigrospora oryzae produces plenty of metabolites [4]. However, there is as yet no study on secondary metabolites isolated from the sponge-associated Nigrospora oryzae.

The strain was cultured in Czapek–Dox medium at room temperature for 40 days in artificial seawater. The culture broth was extracted three times with EtOAc, and the EtOAc solvent was removed under vacuum to yield...


CDCl3 Secondary Metabolite EtOAc CD3OD Diketopiperazines 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was financially supported by grants from the National Marine ‘863’ Project (2013AA092902), the National Natural Science Foundation of China (21172094, 41376155, 21372100, U1301131), and the Science and Technology Program of Guangzhou, China (2006Z-E4041).


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Lijian Ding
    • 1
    • 2
  • Wei Yuan
    • 3
  • Qi Peng
    • 2
  • Huan Sun
    • 2
  • Shihai Xu
    • 2
  1. 1.College of PharmacyJinan UniversityGuangzhouP. R. China
  2. 2.Department of ChemistryJinan UniversityGuangzhouP. R. China
  3. 3.Key Laboratory for Marine Drugs, Department of Pharmacy, State Key Laboratory of Oncogenes and Related Genes, Ren Ji Hospital, School of MedicineShanghai Jiao Tong UniversityShanghaiP. R. China

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