Synthesis and Analgesic Activity of 4,7-Dimethyl-3,4,4a,5,8,8a-Hexahydro-2H-Chromen-4,8-Diols Containing Thiophene Substituents
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Hexahydro-2H-chromenes with thiophene fragments were synthesized via reactions of a p-menthane monoterpenoid diol with several thiophenecarboxaldehydes. Most of the synthesized compounds with an additional thiophene fragment displayed analgesic activity in vivo tests at a dose of 10 mg/kg. It was found that the activity in either an acetate-writhing test or a hot-plate test depended on the type and location of substituent in the heteroaromatic ring.
Keywordsmonoterpenes thiophenecarboxaldehyde clay heterocyclic compounds analgesic activity
We thank the Russian Foundation for Basic Research for financial support (Grant 15-33-20198) and the Khimiya Center for Collective Use, SB, RAS, for spectral and analytical measurements.
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