Chemistry of Natural Compounds

, Volume 52, Issue 3, pp 487–489 | Cite as

Chemical Constituents of Saussurea involucrata with Anti-Hypoxia Activity

  • Linlin Jing
  • Lei He
  • Pengcheng Fan
  • Zhengping Jia
  • Huiping Ma

Saussurea involucrata (Kar. et Kir.) Sch.-Bip., belonging to the Asteraceae family, or more commonly known as the snow lotus, is a rare traditional Chinese medicinal herb on the verge of extinction and has been listed as a second-grade national protected wild plant in China [1]. According to the theories of traditional Chinese medicine, S. involucrata shows efficacy in warming kidney, activating “yang,” expelling wind, eliminating dampness, inducing menstruation, and promoting blood circulation [2]. Modern pharmacological studies have demonstrated that S. involucrata has lots of activities, such as free radical scavenging, anti-fatigue [3], anti-inflammation [4], and anticancer [5] activities.

Our previous studies have shown that the petroleum ether extract of S. involucrata has significant anti-hypoxia activity [6], but the chemical constituents responsible for this activity are not clear. In the present study, we isolated, elucidated, and identified four flavones with excellent...


CDCl3 PC12 Cell Rutin EtOAc Flavone 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



Financial support from National Natural Science Foundation of China (81202458), China Postdoctoral Science Foundation (2012M521926), and Scientific Research Foundation of Gansu Province (1308RJYA061) is gratefully acknowledged.


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Copyright information

© Springer Science+Business Media New York 2016

Authors and Affiliations

  • Linlin Jing
    • 1
  • Lei He
    • 1
  • Pengcheng Fan
    • 1
  • Zhengping Jia
    • 1
  • Huiping Ma
    • 1
  1. 1.Department of PharmacyLanzhou General Hospital, Lanzhou Command of CPLALanzhouP. R. China

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