Bioactive Perylene Derivatives from a Soft Coral-Derived Fungus Alternaria sp. (ZJ-2008017)
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Marine-derived fungi have proved to be a promising source of structurally novel and biologically active secondary metabolites that have become interesting and significant resources for drug discovery [1, 2]. Perylene derivatives have been isolated from the marine-derived fungi of the genera of Alternaria and Stemphylium [3, 4]. They are of ten were found to have a partially reduced perylene quinone skeleton, and such perylene derivatives sometimes show a variety of phytotoxins and mutagenic activities .
As part of our ongoing investigation into new natural products, a series of antibacterial, antifouling, and cytotoxic compounds have been isolated from marine-derived fungi from the South China Sea [5, 6, 7, 8, 9, 10, 11]. Chemically-induced teratogenicity is preventable with proactive reproductive safety evaluations. The developing zebrafish (Daniorerio) is an in vivo developmental model with a number of advantages over in vitrosystems and provides a simple, inexpensive, and rapid...
KeywordsEtOAc Perylene Zebrafish Embryo Soft Coral EtOAc Extract
We thank Dr. Ying Xu, Division of Life Science, the Hong Kong University of Science and Technology, China, for antifouling bioassay. We acknowledge funding from the Program of National Natural Science Foundation of China (Nos. 41130858; 40976077), Natural Science Foundation of Shandong Province (ZR2011HM085), and Guangdong Special Financial Fund of Innovative Development of Marine Economic Demonstration Project (GD2012-D01-001).
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