Chemistry of Natural Compounds

, Volume 51, Issue 2, pp 302–305 | Cite as

Beilschamide, a New Amide, and Cytotoxic Constituents of Beilschmiedia erythrophloia

  • Jih-Jung Chen
  • Wen-Lung Kuo
  • Ping-Jyun Sung
  • Ih-Sheng Chen
  • Ming-Jen Cheng
  • Yun-Ping Lim
  • Hsiang-Ruei Liao
  • Tsung-Hsien Chang
  • Dau-Chang Wei
  • Jhy-Yih Chen

A new amide, beilschamide (1), has been isolated from the stem of Beilschmiedia erythrophloia, together with seven known compounds, N-trans-feruloyltyramine (2), N-trans-feruloyloctopamine (3), vanillin (4), α-tocopheryl quinone (5), β-sitostenone (6), β-sitosterol (7), and 6α-hydroxystigmast-4-en-3-one (8). The structure of the new compound 1 was determined through spectroscopic and MS analyses. N-trans-Feruloyloctopamine (3) and beilschamide (1) exhibited cytotoxic effects with IC50 values of 10.3 and 21.2 μg/mL, respectively, against CCRF-CEM cell line.


Beilschmiedia erythrophloia amide beilschamide 



This research was supported by Grants from the National Science Council of the Republic of China (No. NSC 98-2320-B-127-001-MY3 and NSC 101-2320-B-127-001-MY3), awarded to Prof. J.-J. Chen.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Jih-Jung Chen
    • 1
  • Wen-Lung Kuo
    • 2
  • Ping-Jyun Sung
    • 3
  • Ih-Sheng Chen
    • 4
  • Ming-Jen Cheng
    • 5
  • Yun-Ping Lim
    • 6
  • Hsiang-Ruei Liao
    • 7
  • Tsung-Hsien Chang
    • 8
  • Dau-Chang Wei
    • 1
  • Jhy-Yih Chen
    • 1
  1. 1.Graduate Institute of Pharmaceutical Technology & Department of PharmacyTajen UniversityPingtungTaiwan
  2. 2.Chung-Jen Junior College of NursingHealth Sciences and ManagementChiayiTaiwan
  3. 3.National Museum of Marine Biology and AquariumPingtungTaiwan
  4. 4.School of Pharmacy, College of PharmacyKaohsiung Medical UniversityKaohsiungTaiwan
  5. 5.Bioresource Collection and Research Center (BCRC), Food Industry Research and Development Institute (FIRDI)HsinchuTaiwan
  6. 6.School of Pharmacy, College of PharmacyChina Medical UniversityTaichungTaiwan
  7. 7.Graduate Institute of Natural ProductsChang Gung UniversityTaoyuanTaiwan
  8. 8.Laboratory of Infectious Disease and ImmunologyKaohsiung Veterans General HospitalKaohsiungTaiwan

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