Advertisement

Chemistry of Natural Compounds

, Volume 50, Issue 6, pp 1075–1078 | Cite as

Two New Diketopiperazines from ARUM Palaestinum

  • Samy K. El-Desouky
  • Usama W. Hawas
  • Young-Kyoon Kim
Article

The phytochemical investigation of the water extract of Arum palaestinum led to the isolation of three compounds identified as isoorientin (luteolin 6-C-β-D-glucopyranoside), vitexin (apigenin 8-C-β-Dglucopyranoside), and vicenin II (apigenin 6,8-di-C-β-D-glucopyranoside) as well as two new diketopiperazines (DKP), namely 3-hydroxypiperazine-2,5-dione (1) and piperazine-2,5-dione (2). The chemical structures of the isolated compounds were established by spectroscopic methods including IR, MS, and NMR. The new diketopiperazine (1) exhibited mild cytotoxic activity against human multidrug-resistant cell line MES-SA/DX5 with ED50 3.44 μM.

Keywords

Arum palaestinum diketopiperazine cytotoxicity multidrug-resistant cells 

Notes

Acknowledgment

This study was supported in part by a 2012 Kookmin University Research Grant and a Grant (S211313L010110) from Forest Science & Technology Projects, Forest Service. Republic of Korea.

References

  1. 1.
    S. K. El-Desouky, S. Y. Ryub, and Y. K. Kim, Tetrahedron Lett., 48, 4015 (2007).CrossRefGoogle Scholar
  2. 2.
    N. T. H. Van, C. V. Minh, and M. D. Leo, Biochem. Syst. Ecol., 34, 882 (2006).CrossRefGoogle Scholar
  3. 3.
    M. Hudaib, M. Mohammad, Y. Bustanji, R. Tayyem, M. Yousef, M. Abuirjeie, and T. Aburjai, J. Ethnopharmacol., 120, 63 (2008).PubMedCrossRefGoogle Scholar
  4. 4.
    M. S. Ali-Shtayeh and R. M. Jamous, Eur. J. Integr. Med., 3, 125 (2011).CrossRefGoogle Scholar
  5. 5.
    F. U. A, E. Khalil, and S. Abdalla, J. Ethnopharmacol., 65, 173 (1999).Google Scholar
  6. 6.
    S. K. El-Desouky, K. H. Kim, S. Y. Ryu, A. F. Eweas, A. M. Gamal-Eldeen, and Y. K. Kim, Arch. Pharm. Res., 30, 927 (2007).PubMedCrossRefGoogle Scholar
  7. 7.
    D. Sorensen, T. O. Larsen, C. Christophersen, P. H. Nielsen, and U. Anthoni, Phytochemistry, 51, 1181 (1999).CrossRefGoogle Scholar
  8. 8.
    B. S. Antia, T. Aree, C. Kasettrathat, S. Wiyakrutta, O. D. Ekpa, U. J. Ekpe, C. Mahidol, S. Ruchirawat, and P. Kittakoop, Phytochemistry, 72, 816 (2011).PubMedCrossRefGoogle Scholar
  9. 9.
    S. U. Choi, N. Y. Kim, E. J. Choi, K. H. Kim, and J. O. Lee, Arch. Pharm. Res., 19, 342 (1996).CrossRefGoogle Scholar
  10. 10.
    S. Y. Ryu, S. U. Choi, C. O. Lee, and O. P. Zee, Arch. Pharm. Res., 15, 356 (1992).CrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Samy K. El-Desouky
    • 1
    • 3
  • Usama W. Hawas
    • 2
    • 3
  • Young-Kyoon Kim
    • 4
  1. 1.Chemistry Department, Faculty of ScienceJazan University-JazanSaudi Arabia
  2. 2.Marine Chemistry Department, Faculty of Marine SciencesKing Abdulaziz UniversityJeddahSaudi Arabia
  3. 3.Phytochemistry and Plant Systematic DepartmentNational Research CentreCairoEgypt
  4. 4.Forest Products Department, College of Forest ScienceKookmin UniversitySeoulKorea

Personalised recommendations