Chemistry of Natural Compounds

, Volume 50, Issue 6, pp 1075–1078 | Cite as

Two New Diketopiperazines from ARUM Palaestinum

  • Samy K. El-Desouky
  • Usama W. Hawas
  • Young-Kyoon Kim

The phytochemical investigation of the water extract of Arum palaestinum led to the isolation of three compounds identified as isoorientin (luteolin 6-C-β-D-glucopyranoside), vitexin (apigenin 8-C-β-Dglucopyranoside), and vicenin II (apigenin 6,8-di-C-β-D-glucopyranoside) as well as two new diketopiperazines (DKP), namely 3-hydroxypiperazine-2,5-dione (1) and piperazine-2,5-dione (2). The chemical structures of the isolated compounds were established by spectroscopic methods including IR, MS, and NMR. The new diketopiperazine (1) exhibited mild cytotoxic activity against human multidrug-resistant cell line MES-SA/DX5 with ED50 3.44 μM.


Arum palaestinum diketopiperazine cytotoxicity multidrug-resistant cells 



This study was supported in part by a 2012 Kookmin University Research Grant and a Grant (S211313L010110) from Forest Science & Technology Projects, Forest Service. Republic of Korea.


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Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Samy K. El-Desouky
    • 1
    • 3
  • Usama W. Hawas
    • 2
    • 3
  • Young-Kyoon Kim
    • 4
  1. 1.Chemistry Department, Faculty of ScienceJazan University-JazanSaudi Arabia
  2. 2.Marine Chemistry Department, Faculty of Marine SciencesKing Abdulaziz UniversityJeddahSaudi Arabia
  3. 3.Phytochemistry and Plant Systematic DepartmentNational Research CentreCairoEgypt
  4. 4.Forest Products Department, College of Forest ScienceKookmin UniversitySeoulKorea

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