Chemistry of Natural Compounds

, Volume 48, Issue 2, pp 245–249 | Cite as

Synthetic transformations of sesquiterpene lactones. V.* Synthesis and cytotoxicity of 13-aryl-substituted tourneforin derivatives

  • E. E. Shulˈts
  • S. S. Patrushev
  • A. V. Belovodskii
  • M. M. Shakirov
  • T. V. Rybalova
  • A. G. Pokrovskii
  • M. A. Pokrovskii
  • G. A. Tolstikov
  • S. M. Adekenov
Article

13-Aryl-substituted tourneforin derivatives were synthesized via the Heck reaction with aryliodides. The structure of (E)-13-(3,4-dimethoxybenzyl)-eudesma-4(5),11(13)-dien-6α,12-olide was confirmed by an XSA. A study of the cytotoxicity of the synthesized derivatives for CEM-13, MT-4, and U-937 tumor models showed promise for the modification.

Keywords

tourneforin Heck reaction 13-aryleudesmanolides tumor cells XSA 

Notes

Acknowledgment

The work was supported financially by an Integrated Project of the SB, RAS, with organizations of CIS countries (No. 79).

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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • E. E. Shulˈts
    • 1
  • S. S. Patrushev
    • 1
    • 2
  • A. V. Belovodskii
    • 1
  • M. M. Shakirov
    • 1
  • T. V. Rybalova
    • 1
  • A. G. Pokrovskii
    • 2
  • M. A. Pokrovskii
    • 2
  • G. A. Tolstikov
    • 1
  • S. M. Adekenov
    • 3
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian BranchRussian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia
  3. 3.International Scientific-Production Holding FitokhimiyaKaragandaRepublic of Kazakhstan

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