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Chemistry of Natural Compounds

, 47:541 | Cite as

Bioactive metabolites from Penicillium sp. P-1, a fungal endophyte in Huperzia serrata

  • You-Min Ying
  • Zha-Jun Zhan
  • Zhi-Shan Ding
  • Wei-Guang Shan
Article

A chemical study of metabolites of the strain Penicillium sp. P-1, an endophyte from the stems of Huperzia serrata, furnished a new chromone derivative, (2S)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]- chroman-4-one (1), an enantiomer of a known compound, and seven known compounds 2–8. The structure and absolute configuration of 1 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Cytotoxic activity of compounds 1–3 against HeLa and HepG2 cell lines were evaluated, in which compounds 2 and 3 exhibited marked cytotoxic activity against HeLa cells.

Keywords

endophytes Penicillium sp. Huperzia serrata cytotoxic 

Notes

Acknowledgment

The financial support of Zhejiang Provincial Top Key Pharmaceutical Discipline Open Foundation is gratefully acknowledged.

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • You-Min Ying
    • 1
  • Zha-Jun Zhan
    • 1
  • Zhi-Shan Ding
    • 2
  • Wei-Guang Shan
    • 1
  1. 1.College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhouP. R. China
  2. 2.College of Life ScienceZhejiang Chinese Medical UniversityHangzhouP. R. China

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