Chemistry of Natural Compounds

, 47:541 | Cite as

Bioactive metabolites from Penicillium sp. P-1, a fungal endophyte in Huperzia serrata

  • You-Min Ying
  • Zha-Jun Zhan
  • Zhi-Shan Ding
  • Wei-Guang ShanEmail author

A chemical study of metabolites of the strain Penicillium sp. P-1, an endophyte from the stems of Huperzia serrata, furnished a new chromone derivative, (2S)-2,3-dihydro-7-hydroxy-6,8-dimethyl-2-[(E)-prop-1-enyl]- chroman-4-one (1), an enantiomer of a known compound, and seven known compounds 2–8. The structure and absolute configuration of 1 were established using spectroscopic methods, including extensive 2D NMR and CD analyses. Cytotoxic activity of compounds 1–3 against HeLa and HepG2 cell lines were evaluated, in which compounds 2 and 3 exhibited marked cytotoxic activity against HeLa cells.


endophytes Penicillium sp. Huperzia serrata cytotoxic 



The financial support of Zhejiang Provincial Top Key Pharmaceutical Discipline Open Foundation is gratefully acknowledged.


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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • You-Min Ying
    • 1
  • Zha-Jun Zhan
    • 1
  • Zhi-Shan Ding
    • 2
  • Wei-Guang Shan
    • 1
    Email author
  1. 1.College of Pharmaceutical ScienceZhejiang University of TechnologyHangzhouP. R. China
  2. 2.College of Life ScienceZhejiang Chinese Medical UniversityHangzhouP. R. China

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