Chemical constituents from the antitumor fraction of Trachyrhamphus serratus
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Trachyrhamphus serratus Temminck et Schlegel, a pipefish widely distributing in Western Pacific Ocean and Northern Indian Ocean, has been used for the treatment of impotence and tumor for more than 500 years in China [1,2]. It was reported that the ethanol extract of Trachyrhamphus serratus showed obvious antitumor activity in vivo  and in vitro . Moreover, the active components were confirmed in the petroleum ether soluble fraction of the ethanol extract according to active-guided screening in our preliminary studies . In order to find the antitumor constituents, chemical separation was carried out on the petroleum ether fraction. As a result, 12 compounds were isolated and identified, including a new natural product 9. Compounds 2–12 were obtained from Trachyrhamphus serratus, and compound 6 was found in the vertebrate for the first time.
The dried Trachyrhamphus serratuswas obtained from Haikou, Hannan province of China, in November, 2005 and was authenticated by one of...
KeywordsCDCl3 Ethanol Extract Squalene Petroleum Ether Extract Western Pacific Ocean
This work was supported by the National Natural Science Foundation of China (No. 30672620) and the Shanghai Scientific Committee – Korea SK Research & Development Foundation (No.200312 t).
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