Chemical constituents from the antitumor fraction of Trachyrhamphus serratus

  • Mengyue Wang
  • Yunjin He
  • Yuxiao Nie
  • Xiaobo Li

Trachyrhamphus serratus Temminck et Schlegel, a pipefish widely distributing in Western Pacific Ocean and Northern Indian Ocean, has been used for the treatment of impotence and tumor for more than 500 years in China [1,2]. It was reported that the ethanol extract of Trachyrhamphus serratus showed obvious antitumor activity in vivo [3] and in vitro [4]. Moreover, the active components were confirmed in the petroleum ether soluble fraction of the ethanol extract according to active-guided screening in our preliminary studies [5]. In order to find the antitumor constituents, chemical separation was carried out on the petroleum ether fraction. As a result, 12 compounds were isolated and identified, including a new natural product 9. Compounds 2–12 were obtained from Trachyrhamphus serratus, and compound 6 was found in the vertebrate for the first time.

The dried Trachyrhamphus serratuswas obtained from Haikou, Hannan province of China, in November, 2005 and was authenticated by one of...


CDCl3 Ethanol Extract Squalene Petroleum Ether Extract Western Pacific Ocean 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



This work was supported by the National Natural Science Foundation of China (No. 30672620) and the Shanghai Scientific Committee – Korea SK Research & Development Foundation (No.200312 t).


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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Mengyue Wang
    • 1
  • Yunjin He
    • 1
  • Yuxiao Nie
    • 1
  • Xiaobo Li
    • 1
  1. 1.School of PharmacyShanghai Jiao Tong UniversityShanghaiP. R. China

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