Composition, structural characteristics, and antitumor properties of polysaccharides from the brown algae Dictyopteris polypodioides and Sargassum sp.

  • R. V. Sokolova
  • S. P. Ermakova
  • S. M. Awada
  • T. N. Zvyagintseva
  • H. M. Kanaan
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The polysaccharide compositions of the brown algae Dictyopteris polypodioides and Sargassum sp. from the Mediterranean Sea were determined. The principal polysaccharide of the studied algae (about 12% of the dry alga weight) was alginic acid. The content of water-soluble polysaccharides was low. The amount of fucoidan was less than 1% of the dry alga weight; of neutral polysaccharides, less than 0.25%. The monosaccharide compositions of fucoidans and neutral polysaccharides were investigated. Experiments on soft agar-agar models showed that fucoidans from D. polypodioides and Sargassum sp. exhibited antitumor activity against RPMI-7951 human melanoma cells.

Keywords

brown algae polysaccharides Dictyopteris Sargassum laminaran fucoidan alginic acid biological activity 

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • R. V. Sokolova
    • 1
  • S. P. Ermakova
    • 1
  • S. M. Awada
    • 2
  • T. N. Zvyagintseva
    • 1
  • H. M. Kanaan
    • 2
  1. 1.Pacific Institute of Bioorganic Chemistry, Far-East DivisionRussian Academy of SciencesVladivostokRussia
  2. 2.Laboratory of Biotechnology of Natural Substances and Health Products, Faculty of PharmacyLebanese UniversityBeirutLebanon

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