Lithiation of deoxypeganine and chiral synthesis of deoxypeganine derivatives
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A method was developed for lithiation of deoxypeganine. The reaction of organolithium deoxypeganine derivatives with isobutyraldehyde and benzaldehyde to produce its derivatives was studied. A chiral synthesis of substituted deoxypeganines was performed. The synthesized diastereomers and enantiomers were separated successfully using HPLC and a chiral column.
Keywordsdeoxypeganine lithiation enantiomers racemates configuration
The work was supported by the INTAS Foundation (YSF Collaborative Call with Uzbekistan 2006, for a Ph.D. Fellowship INTAS Ref. No. 06-1000023-6035).
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