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Chemistry of Natural Compounds

, Volume 46, Issue 6, pp 929–931 | Cite as

Lithiation of deoxypeganine and chiral synthesis of deoxypeganine derivatives

  • Kh. M. Shakhidoyatov
  • I. Coldham
  • T. F. Ibragimov
Article

A method was developed for lithiation of deoxypeganine. The reaction of organolithium deoxypeganine derivatives with isobutyraldehyde and benzaldehyde to produce its derivatives was studied. A chiral synthesis of substituted deoxypeganines was performed. The synthesized diastereomers and enantiomers were separated successfully using HPLC and a chiral column.

Keywords

deoxypeganine lithiation enantiomers racemates configuration 

Notes

Acknowledgment

The work was supported by the INTAS Foundation (YSF Collaborative Call with Uzbekistan 2006, for a Ph.D. Fellowship INTAS Ref. No. 06-1000023-6035).

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Kh. M. Shakhidoyatov
    • 1
  • I. Coldham
    • 2
  • T. F. Ibragimov
    • 1
  1. 1.S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkentUzbekistan
  2. 2.Department of ChemistryUniversity of SheffieldSheffieldUK

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