Chemistry of Natural Compounds

, Volume 46, Issue 6, pp 929–931 | Cite as

Lithiation of deoxypeganine and chiral synthesis of deoxypeganine derivatives

  • Kh. M. Shakhidoyatov
  • I. Coldham
  • T. F. Ibragimov

A method was developed for lithiation of deoxypeganine. The reaction of organolithium deoxypeganine derivatives with isobutyraldehyde and benzaldehyde to produce its derivatives was studied. A chiral synthesis of substituted deoxypeganines was performed. The synthesized diastereomers and enantiomers were separated successfully using HPLC and a chiral column.


deoxypeganine lithiation enantiomers racemates configuration 



The work was supported by the INTAS Foundation (YSF Collaborative Call with Uzbekistan 2006, for a Ph.D. Fellowship INTAS Ref. No. 06-1000023-6035).


  1. 1.
    X. Wu, Y. Liu, W. Sheng, J. Sun, and G. Qin, Planta Med., 63, 55 (1997).PubMedCrossRefGoogle Scholar
  2. 2.
    K. Deng, X. Wu, G. Yang, and G. Qin, Chin. Chem. Lett., 8, 237 (1997).Google Scholar
  3. 3.
    Kh. M. Shakhidoyatov, A. Irisbaev, L. M. Yun, E. Oripov, and Ch. Sh. Kadyrov, Khim. Geterotsikl. Soedin., 1564 (1976).Google Scholar
  4. 4.
    B. Zh. Elmuradov, Dissertation, Tashkent, 2003.Google Scholar
  5. 5.
    S. V. Shevyakov, O. I. Davydova, A. S. Kiselyov, D. V. Kravchenko, A. V. Ivachtchenko, and M. Krasavin, Nat. Prod. Res., 871 (2006).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  • Kh. M. Shakhidoyatov
    • 1
  • I. Coldham
    • 2
  • T. F. Ibragimov
    • 1
  1. 1.S. Yu. Yunusov Institute of the Chemistry of Plant Substances, Academy of Sciences of the Republic of UzbekistanTashkentUzbekistan
  2. 2.Department of ChemistryUniversity of SheffieldSheffieldUK

Personalised recommendations