Antibacterial activity of the chemical constituents from Ranunculus laetus
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The genus Ranunculus belongs to the family Ranunculaceae, which comprises 50 genera and 2000 species, distributed throughout the northern hemisphere. It is also found in southern temperate regions in the tropics where they are usually confined to higher altitudes. In Pakistan, it is represented by 22 genera and about 114 species, of which several genera are of ornamental value while the others are toxic and used for medicinal purposes .
The plant Ranunculus laetus was collected from the Parachinar Kurram Agency, Pakistan, in April-May 2001, and was identified by Dr. Jahandar Shah (plant taxonomist) at the Department of Botany, University of Peshawar, Pakistan. The chloroform extract (86 g) was subjected to column chromatography using different solvent systems. The eluent obtained with n-hexane–CHCl3 (8:2, v/v), was again subjected to silica gel column chromatography to obtain compounds 1–6. These compounds were three known flavone jacein (1) , jacedin-5-O-β-D-glucoside (2) ,...