Abstract
Alkylidene derivatives of cardiac glycosides were synthesized for increased lipophilicity. The synthesis was based on reaction of aldehydes and ketones with the natural glycosides erysimin, digoxin, and digoxigenin-bis-digitoxoside. A total of 19 biologically active compounds was prepared.
Key words
cardenolides cardenolide-glycosides alkylidene derivatives erysimin isopropylidene-erysimin bioavailability absorption from gastrointestinal (GI) tract biological activityPreview
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References
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