Chemistry of Natural Compounds

, Volume 42, Issue 3, pp 316–321 | Cite as

Chemical structure and biological activity of steroidal saponins from Furcraea gigantea

  • Bernadete Pereira da Silva
  • Patricia Oliveira Campos
  • Jose Paz Parente
Article
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Abstract

A new bisdesmosidic furostanol saponin, along with a known spirostanol saponin, furcreastatin, were isolated from Furcraea gigantea Vent. (Agavaceae). The structure of the new saponin was elucidated as 3-[(O-6-deoxy-α-L-mannopyranosyl-(1→4)-O-β-D-glucopyranosyl-(1å 3)-O-[O-β-D-glucopyranosyl-(1→3)-β-D-glucopyranosyl-(1→2)-O-β-D-glucopyranosyl-(1→4)-β-D-galactopyranosyl)oxy]-(3β, 5α, 25R)-26-(β-D-glucopyranosyloxy)-22-hydroxyfurost-12-one. The structural identification was performed using a combination of spectroscopic techniques and chemical conversions. Furcreastatin showed a powerful haemolytic effect in the in vitro assay, but the new bisdesmosidic furostanol saponin demonstrated only a significant inhibition of the capillary permeability activity.

Key words

Furcraea gigantea steroidal saponins structural elucidation biological activity 
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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Bernadete Pereira da Silva
    • 1
  • Patricia Oliveira Campos
    • 1
  • Jose Paz Parente
    • 1
  1. 1.Laboratorio de Quimica de Plantas Medicinais, Nucleo de Pesquisas de Produtos Naturais, Centro de Ciencias da SaudeUniversidade Federal do Rio de JaneiroRio de JaneiroBrasil

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