Phenolic glycosides of Juncus acutus and its anti-eczematic activity
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The total alcohol extract of Juncus acutus L. showed significant anti-eczematic activity. The isolation of the five phenolic glycosides which responsible for this activity were isolated and identified as oxyresveratrol 2-O-β-D-glucopyranoside (1), resveratrol 3′,4′-O,O′-di-β-D-glucopyranoside (2), markhamioside F (3), canthoside B (4), and caffeic acid glucorhamnoside (5). The toxic effect of the alcohol extract of the plant was studied on mice to determine their LD50, which proved to be nontoxic up to 3000 mg/kg body weight. The anti-eczematic activity of the isolated compounds was tested in mice and showed variable effect. Compounds 3 and 4 were found to have the highest activity; they cured eczema by 90 and 100% respectively.
Key wordsphenolic glycosides anti-eczematic Juncus acutus
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