Chemistry of Natural Compounds

, Volume 42, Issue 2, pp 152–155 | Cite as

Phenolic glycosides of Juncus acutus and its anti-eczematic activity

  • Amani S. Awaad


The total alcohol extract of Juncus acutus L. showed significant anti-eczematic activity. The isolation of the five phenolic glycosides which responsible for this activity were isolated and identified as oxyresveratrol 2-O-β-D-glucopyranoside (1), resveratrol 3′,4′-O,O′-di-β-D-glucopyranoside (2), markhamioside F (3), canthoside B (4), and caffeic acid glucorhamnoside (5). The toxic effect of the alcohol extract of the plant was studied on mice to determine their LD50, which proved to be nontoxic up to 3000 mg/kg body weight. The anti-eczematic activity of the isolated compounds was tested in mice and showed variable effect. Compounds 3 and 4 were found to have the highest activity; they cured eczema by 90 and 100% respectively.

Key words

phenolic glycosides anti-eczematic Juncus acutus 


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    A. Fredga, G. Bendz, and A. Apell (1974). Red pigment in Juncaceae family. Nobel Symp., 194, 25, 121 (through chemical abstract, 82, 82918, 1975).Google Scholar
  2. 2.
    M. Isobel Morice, J. Food Agr., 18(3), 129 (1967).Google Scholar
  3. 3.
    H. Sarkar, M. Zerezghi, and B. Jundabrata, Phytochemistry, 27(9), 3006 (1989).CrossRefGoogle Scholar
  4. 4.
    D. Chapatwala, A. Rmando, and M. Howard, Life Sci., 29(19), 1997 (1981).PubMedCrossRefGoogle Scholar
  5. 5.
    K. Tripetch, S. Kotomi, K. Ryoji, and Y. Kazuo, Chem. Pharm. Bull., 50(6), 863 (2002).CrossRefGoogle Scholar
  6. 6.
    K. Tripetch, K. Ryoji, and Y. Kazuo, Phytochemistry, 59, 55 (2002).Google Scholar
  7. 7.
    K. Tripetch, K. Ryoji, and Y. Kazuo, Phytochemistry, 61, 461 (2002).CrossRefGoogle Scholar
  8. 8.
    H. M. Grace and M. Salwa Nofal, Bull. Fac. Pharm. Cairo Uni., 39(1), 345 (2001).Google Scholar
  9. 9.
    B. Loutfy, Flora of Egypt, II, al Hadara Publishing, Cairo, Egypt, 2000, 249.Google Scholar
  10. 10.
    E. Stahl, Thin-Layer Chromatography, 1969, 2nd ed., George Allon and Unwirid, London, Springer, Berlin.Google Scholar
  11. 11.
    D. J. Finney, Statistical Methods in Biological Assay, Charles, Griffin and Company Ltd., London, 1964, 97.Google Scholar
  12. 12.
    S. El-Dondity, T. Khalifa, H. Ammar, and M. Ashour, Az. J. Pharm. Sci., 24, 230 (1999).Google Scholar

Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • Amani S. Awaad
    • 1
  1. 1.Aromatic and Medicinal Plant DepartmentDesert Research CenterCairoEgypt

Personalised recommendations