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Synthesis of novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro- 2'H,8H-spiro[indolizine-7,3'-thiophen]-8-one derivatives via sulfa-Michael/aldol cascade reactions

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The sulfa-Michael/aldol cascade reaction of (E)-7-arylidene-6,7-dihydroindolizin-8(5H)-ones and 1,4-dithiane-2,5-diol afforded novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro-2'H,8H-spiro[indolizine-7,3'-thiophen]-8-ones in low to moderate yields. The structures of all products were characterized thoroughly by NMR, IR, HRMS, together with X-ray crystallographic analysis.

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Correspondence to Ju-Lan Zeng or Xiaofang Li.

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Published in Khimiya Geterotsiklicheskikh Soedinenii, 2020, 56(1), 42–46

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Huang, Y., Tang, G., Ren, D. et al. Synthesis of novel 2'-aryl-4'-hydroxy-4',5,5',6-tetrahydro- 2'H,8H-spiro[indolizine-7,3'-thiophen]-8-one derivatives via sulfa-Michael/aldol cascade reactions. Chem Heterocycl Comp (2020). https://doi.org/10.1007/s10593-020-02620-9

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Keywords

  • 1,4-dithiane-2,5-diol
  • 6,7-dihydroindolizin-8(5H)-one
  • sulfa-Michael/aldol cascade reaction
  • spiro heterocycle