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Chemistry of Heterocyclic Compounds

, Volume 55, Issue 11, pp 1092–1097 | Cite as

4-(Boc-amino)-1Н-1,2,3-triazole-5-carboxylic acids –convenient reagents for the synthesis of 1,4,6,7-tetrahydro[1,2,3]- triazolo[4,5-е][1,4]diazepine-5,8-diones

  • Natalia А. SyrotaEmail author
  • Sergiy V. Kemskiy
  • Andriy V. Bol’but
  • Mikhailo V. Vovk
Article
  • 9 Downloads

The corresponding ethyl 5-carbonylglycinates were synthesized by condensation of 4-(Boc-amino)-1,2,3-triazole-5-carboxylic acids with ethyl glycinate hydrochloride. They were intramolecularly cyclized with the selective formation of 1,4,6,7-tetrahydro[1,2,3]triazolo[4,5-e]- [1,4]diazepine-5,8-diones.

Keywords

4-amino-1,2,3-triazole-5-carboxylic acids ethyl [4-(Boc-amino)-1H-1,2,3-triazole-5-carbonyl]glycinate [1,2,3]triazolo[4,5-e]- [1,4]diazepine intramolecular cyclization 

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Authors and Affiliations

  • Natalia А. Syrota
    • 1
    Email author
  • Sergiy V. Kemskiy
    • 2
  • Andriy V. Bol’but
    • 2
    • 3
  • Mikhailo V. Vovk
    • 2
  1. 1.National University “Kyiv-Mohyla Academy”KyivUkraine
  2. 2.Institute of Organic ChemistryNational Academy of Sciences of UkraineKyivUkraine
  3. 3.Enamine Ltd.KyivUkraine

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