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One-pot diastereoselective synthesis of functionalized 4,5-dihydropyrroles by reactions of arylglyoxals, β-dicarbonyl compounds, and aromatic amines

  • Nadezhda N. KolosEmail author
  • Sergey A. Karpan
  • Irina V. Omelchenko
  • Natal’ya V. Chechina
  • Feodor G. Yaremenko
Article
  • 9 Downloads

A multicomponent reaction of arylglyoxal hydrates, acetylacetone or acetoacetic ester, aniline or its 3(4)-substituted analogs in 1:1:2 ratio occurred upon stirring in methanol, giving 4-arylamino-5-hydroxypyrroline derivatives containing 4,5-dihydroxypyrrolines as impurities.

Keywords

acetylacetone acetoacetic ester arylglyoxal hydrates 4,5-dihydropyrroles domino reactions 

Notes

Supplementary material

10593_2019_2544_MOESM1_ESM.pdf (377 kb)
ESM 1 (PDF 376 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2019

Authors and Affiliations

  • Nadezhda N. Kolos
    • 1
    Email author
  • Sergey A. Karpan
    • 1
  • Irina V. Omelchenko
    • 1
    • 2
  • Natal’ya V. Chechina
    • 1
  • Feodor G. Yaremenko
    • 2
  1. 1.V. N. Karazin Kharkiv National UniversityKharkivUkraine
  2. 2.Scientific-Technological Complex “Institute of Monocrystals”National Academy of Sciences of UkraineKharkivUkraine

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