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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 11, pp 1056–1060 | Cite as

Acidic ionic liquids: highly efficient catalysts for one-pot four-component synthesis of pyrazolo[1,2-b]phthalazines under solvent-free conditions

  • Behjat Pouramiri
  • Reza Ghahramani Far
  • Mahboobeh ZahedifarEmail author
Article
  • 32 Downloads

A series of novel pyrazolo[1,2-b]phthalazine-2-carboxylate derivatives has been synthesized via one-pot four-component reaction of aromatic aldehyde, ethyl or methyl acetoacetate, hydrazine hydrate, and phthalic anhydride in the presence of acidic ionic liquids such as 3-methyl-1-sulfo-1H-imidazol-3-ium chloride, 1,3-disulfo-1H-imidazol-3-ium chloride, and triethyl(sulfo)ammonium chloride as the catalyst. This method involves particular advantages such as environmentally benign catalysts, high yields of product, reusability of ionic liquids with high activity, short reaction times, no hazardous solvent, and easy workup.

Keywords

pyrazolo[1,2-b]phthalazines ionic liquid multicomponent reactions solvent-free 

Notes

Supplementary material

10593_2018_2391_MOESM1_ESM.pdf (5.1 mb)
ESM 1 (PDF 5203 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Behjat Pouramiri
    • 1
  • Reza Ghahramani Far
    • 2
  • Mahboobeh Zahedifar
    • 3
    Email author
  1. 1.Department of ChemistryShahid Bahonar University of KermanKermanIran
  2. 2.Department of ChemistryIslamic Azad University of KermanKermanIran
  3. 3.Department of Chemistry, Faculty of ScienceUniversity of JiroftJiroftIran

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