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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 10, pp 951–955 | Cite as

Synthesis and Antifungal Activity of 3-substituted 5-ferrocenyl-1H-pyrazoles

  • Man Ge
  • Hailian Huang
  • Xiaofeng Gou
  • Chengwen Hua
  • Bang Chen
  • Junlong ZhaoEmail author
Article
  • 45 Downloads

A convenient method for the selective synthesis of functionalized 3-substituted 5-ferrocenyl-1H-pyrazoles has been developed. Condensation reaction of α,β-unsaturated ferrocenyl ketones and tosylhydrazine in the presence of catalytic amount of iron(III) phthalocyanine chloride allowed to obtain nine new 3-substituted 5-ferrocenyl-1H-pyrazoles. The synthesized products were evaluated for their antifungal activity against Gibberella nicotiancola, Fusarium oxysporum f. sp. niveum, and Gibberella saubinetii. Most of the compounds exhibited excellent antifungal activity.

Keywords

ferrocene iron(III) phthalocyanine chloride pyrazole antifungal activity 

Notes

The financial support by the National Natural Science Foundation of China (project 21703171), the Foundation of Shaanxi Educational Committee (project 2013JK0975), and the Natural Science Basic Research Plan in Shaanxi Province of China (project 2018JQ2043) is gratefully acknowledged.

Supplementary material

10593_2018_2379_MOESM1_ESM.pdf (1.3 mb)
ESM 1 (PDF 1378 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Man Ge
    • 1
    • 2
  • Hailian Huang
    • 1
  • Xiaofeng Gou
    • 1
  • Chengwen Hua
    • 1
  • Bang Chen
    • 1
  • Junlong Zhao
    • 1
    Email author
  1. 1.Key Laboratory of Synthetic and Natural Functional Molecule Chemistry of Ministry of Education, College of Chemistry & Materials ScienceNorthwest UniversityXi’anChina
  2. 2.College of ScienceXi’an University of Architecture and TechnologyXi’anChina

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