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Chemistry of Heterocyclic Compounds

, Volume 54, Issue 9, pp 832–839 | Cite as

Synthesis and aminomethylation of regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones

  • Antonina V. Popova
  • Svitlana P. Bondarenko
  • Mykhaylo S. Frasinyuk
Article
  • 20 Downloads

The regioisomeric 6-hydroxy-4-methyl- and 4-hydroxy-6-methylaurones were synthesized. Aminomethylation by the action of aminals of secondary amines was investigated. It was shown that the reaction proceeds selectively with the formation of 7-aminomethyl-6-hydroxy-4-methyl- and 5-aminomethyl-4-hydroxy-6-methylaurones, respectively. The use of an excess of the aminals allows to obtain 5,7-bis(aminomethyl) derivatives of 6-hydroxy-4-methylaurones.

Keywords

benzofuran-3(2Н)-one 4-hydroxy-6-methylaurone 6-hydroxy-4-methylaurone aminomethylation Mannich bases 

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Antonina V. Popova
    • 1
  • Svitlana P. Bondarenko
    • 2
  • Mykhaylo S. Frasinyuk
    • 1
  1. 1.V. P. Kukhar Institute of Bioorganic Chemistry and PetrochemistryNational Academy of Sciences of UkraineKyivUkraine
  2. 2.National University of Food TechnologiesKyivUkraine

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