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Chemistry of Heterocyclic Compounds

, Volume 53, Issue 3, pp 371–377 | Cite as

Synthesis and biological activity of heterocyclic borneol derivatives

  • Anastasiya S. SokolovaEmail author
  • Olga I. Yarovaya
  • Anna A. Shtro
  • Marina S. Borisova
  • Ekaterina A. Morozova
  • Tatyana G. Tolstikova
  • Vladimir V. Zarubaev
  • Nariman F. Salakhutdinov
Article
A series of novel heterocyclic derivatives of (–)-borneol has been prepared by the interaction of (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]-heptan-2-yl 2-chloroacetate and (1S,2R,4S)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-yl 3-chloropropanoate with different N- and S-nucleophiles. The obtained products were screened for antiviral, antiulcer, and analgesic activity.

Keywords

1H-benzimidazole-2-thiol benzoxazole-2-thiol benzthiazole-2-thiol (–)-borneol analgesic activity antiulcer activity antiviral activity 

Notes

This work was supported by the Russian Foundation for Basic Research (grant No. 15-03-00193).

Supplementary material

10593_2017_2063_MOESM1_ESM.pdf (2.5 mb)
ESM 1 (PDF 2578 kb)

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Copyright information

© Springer Science+Business Media New York 2017

Authors and Affiliations

  • Anastasiya S. Sokolova
    • 1
    • 2
    Email author
  • Olga I. Yarovaya
    • 1
    • 2
  • Anna A. Shtro
    • 3
  • Marina S. Borisova
    • 1
  • Ekaterina A. Morozova
    • 1
  • Tatyana G. Tolstikova
    • 1
  • Vladimir V. Zarubaev
    • 3
  • Nariman F. Salakhutdinov
    • 1
    • 2
  1. 1.N. N. Vorozhtsov Novosibirsk Institute of Organic ChemistrySiberian Branch of the Russian Academy of SciencesNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia
  3. 3.Department of ChemotherapyResearch Institute of InfluenzaSaint PetersburgRussia

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