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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 7, pp 672–677 | Cite as

Formation of magnetoliposomes using self-assembling 1,4-dihydropyridine derivative and maghemite γ-Fe2O3 nanoparticles

  • Oksana Petrichenko
  • Aiva Plotniece
  • Karlis Pajuste
  • Velta Ose
  • Andrejs Cēbers
Article
  • 120 Downloads

This work demonstrates studies of ferromagnetic nanoparticle functionalization by a lipid-like compound, cationic pyridine amphiphile derived from 1,4-dihydropyridine, 1,1'-{[3,5-bis(dodecyloxycarbonyl)-4-phenyl-1,4-dihydropyridine-2,6-diyl]dimethanediyl}dipyridinium dibromide, and determination of optimal conditions for the production of magnetoliposomes. The following methodologies, such as sonication, spontaneous swelling, and reverse-phase evaporation, were used for the preparation of liposomes. Ferrofluid containing γ-Fe2O3 nanoparticles with a positively charged surface was used for the preparation of magnetoliposomes. The obtained soft matter objects were studied by optical microscopy, transmission electron microscopy, and dynamic light scattering techniques. The optimal conditions for the production of magnetoliposomes were found by spontaneous swelling and reverse-phase evaporation methods using ferrofluid with positively charged γ-Fe2O3 nanoparticles and cationic 1,4-dihydropyridine derivative.

Keywords

cationic 1,4-dihydropyridine ferrofluid magnetoliposomes reverse-phase evaporation method spontaneous swelling method 

Notes

The support from OSMOSE program No 22497YE and INNOVABALT (REGPOT – CT-2013-316149) project (for O. Petrichenko) is gratefully acknowledged. The authors are indebted to M. Maiorov from Institute of Physics of the University of Latvia for the measurement of magnetic properties of nanoparticles and B. Skrivele from the Latvian Institute of Organic Synthesis for the registration of AFM images.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Oksana Petrichenko
    • 1
    • 2
  • Aiva Plotniece
    • 1
  • Karlis Pajuste
    • 1
  • Velta Ose
    • 3
  • Andrejs Cēbers
    • 2
  1. 1.Latvian Institute of Organic SynthesisRigaLatvia
  2. 2.University of LatviaRigaLatvia
  3. 3.Latvian Biomedical Research and Study CentreRigaLatvia

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