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Chemistry of Heterocyclic Compounds

, Volume 51, Issue 5, pp 457–461 | Cite as

A novel method for the domino synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles and studies of stereochemical characteristics of formation and structure thereof

  • Mikhail Yu. Ievlev
  • Oleg V. Ershov
  • Angelina G. Milovidova
  • Mikhail Yu. Belikov
  • Oleg E. Nasakin
Article

A novel universal method for the preparative synthesis of 6-imino-2,7-dioxabicyclo[3.2.1]octane-4,4,5-tricarbonitriles was developed, previously unknown 1- and 8-aryl-substituted derivatives were synthesized, stereochemical characteristics of this transformation were studied, and the reasons for its diastereoselectivity were identified.

Keywords

2,7-dioxabicyclo[3.2.1]octane 4-oxoalkane-1,1,2,2-tetracarbonitriles cytotoxicity diastereoselectivity domino reactions iminolactone ring 

Notes

This study was performed within the framework of the baseline of the State assignment № 872 of the Ministry of Education and Science of the Russian Federation.

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Mikhail Yu. Ievlev
    • 1
  • Oleg V. Ershov
    • 1
  • Angelina G. Milovidova
    • 1
  • Mikhail Yu. Belikov
    • 1
  • Oleg E. Nasakin
    • 1
  1. 1.Chuvash State University named after I. N. UlyanovCheboksaryRussia

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