Chemistry of Heterocyclic Compounds

, Volume 51, Issue 4, pp 385–388 | Cite as

Enantioselective formal synthesis of doxapram

The use of LiHMDS with equimolar amount of sparteine in toluene results in the formation of enantiomerically enriched γ-lactam, a useful synthon for the synthesis of (R)-(+)-doxapram.


doxapram lactam intramolecular alkylation stereoselective synthesis 


This work was supported by Galleon Pharmaceuticals, Inc. Author thanks Dr. Edgars Suna and Dr. Vita Ozola for the assistance in the preparation of the manuscript.


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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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