Chemistry of Heterocyclic Compounds

, Volume 51, Issue 4, pp 385–388 | Cite as

Enantioselective formal synthesis of doxapram

LETTERS TO THE EDITOR
The use of LiHMDS with equimolar amount of sparteine in toluene results in the formation of enantiomerically enriched γ-lactam, a useful synthon for the synthesis of (R)-(+)-doxapram.

Keywords

doxapram lactam intramolecular alkylation stereoselective synthesis 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  1. 1.Latvian Institute of Organic SynthesisRigaLatvia

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