Chemistry of Heterocyclic Compounds

, Volume 51, Issue 3, pp 275–280 | Cite as

Nucleophilic substitution of nitro group in nitrotriazolotriazines as a model of potential interaction with cysteine-containing proteins

  • Vladimir L. Rusinov
  • Irina M. Sapozhnikova
  • Evgeny N. Ulomskii
  • Natalia R. Medvedeva
  • Vladimir V. Egorov
  • Oleg I. Kiselev
  • Ella G. Deeva
  • Andrey V. Vasin
  • Oleg N. Chupakhin
Article

The nucleophilic susbstitution of nitro group in [1,2,4]triazolo[5,1-c][1,2,4]triazinones upon treatment with cysteine and glutathione was studied as a model for the interaction with thiol groups of virus proteins, which mimics the metabolic transformations of antiviral drug Triazavirin® and its derivatives.

Keywords

azolo[5,1-с]triazines cysteine glutathione nitro compounds Triazavirin metabolic transformations nucleophilic substitution 

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Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Vladimir L. Rusinov
    • 1
    • 2
  • Irina M. Sapozhnikova
    • 1
  • Evgeny N. Ulomskii
    • 1
  • Natalia R. Medvedeva
    • 1
  • Vladimir V. Egorov
    • 3
  • Oleg I. Kiselev
    • 3
  • Ella G. Deeva
    • 3
  • Andrey V. Vasin
    • 3
  • Oleg N. Chupakhin
    • 1
    • 2
  1. 1.Ural Federal University named after the First President of Russia Boris YeltsinYekaterinburgRussia
  2. 2.Institute of Organic SynthesisUral Branch of the Russian Academy of SciencesYekaterinburgRussia
  3. 3.Research Institute of InfluenzaMinistry of Healthcare of the Russian FederationSaint-PetersburgRussia

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