Reduction of Camphthotecine by 1,4-dihydropyridine
- 159 Downloads
Topotecan ( 1) is an antitumor drug, whose cytotoxic action is related to the inhibition of DNA topoisomerase I. The key step in the synthesis of topotecan ( 1) is the reduction of camphthotecine ( 2) to give 1,2,6,7-tetrahydrocamphthotecine ( 3) [ 1]. Published variants of this reduction involve the hydrogenation of compound 2 on either platinum or palladium catalysts at atmospheric or elevated pressure [ 2].
Keywordscamphthotecine 1,4-dihydropyridine topotecan reduction
© Springer Science+Business Media New York 2014