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Chemistry of Heterocyclic Compounds

, Volume 49, Issue 8, pp 1180–1187 | Cite as

Synthesis of 4-amino-substituted tetrahydropyrimido[4,5-d]azocines

  • L. G. Voskressensky
  • M. V. Ovcharov
  • T. N. Borisova
  • A. V. Listratova
  • L. N. Kulikova
  • E. A. Sorokina
  • S. P. Gromov
  • A. V. Varlamov
Article

A method for the preparation of 4-amino-substituted tetrahydropyrimido[4,5-d]azocines containing an aromatic pyrimidine fragment has been developed. It was established that tetrahydropyrido[4,3-d]pyri-midines are cleaved by the action of activated alkynes with the formation of 6-vinylpyrimidines.

Keywords

4-amoinopyrimidoazocine vinylpyrimidine ring cleavage ring enlargement Hofmann cleavage tandem transformation 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • L. G. Voskressensky
    • 1
  • M. V. Ovcharov
    • 1
  • T. N. Borisova
    • 1
  • A. V. Listratova
    • 1
  • L. N. Kulikova
    • 1
  • E. A. Sorokina
    • 1
  • S. P. Gromov
    • 2
  • A. V. Varlamov
    • 1
  1. 1.Peoples’ Friendship University of RussiaMoscowRussia
  2. 2.Photochemistry CenterRussian Academy of SciencesMoscowRussia

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