Chemistry of Heterocyclic Compounds

, Volume 49, Issue 4, pp 561–565

One-pot assembly of 3,5-bis(1H-pyrrol-2-yl)-4H-1,2,4-triazol-4-amines from pyrrolecarbo-nitriles and hydrazine

  • T. E. Glotova
  • D. A. Shabalin
  • M. Yu. Dvorko
  • I. A. Ushakov
  • E. Yu. Schmidt
  • A. V. Ivanov
  • A. I. Mikhaleva
  • B. A. Trofimov
Article

The reaction of pyrrole-2-carbonitriles with hydrazine hydrate in the presence of hydrazine dihydrochloride (ethylene glycol, 130-132°С, 1-2 h, argon atmosphere) affords the hitherto unknown 3,5-bis(1H-pyrrol-2-yl)-4H-1,2,4-triazol-4-amines in up to 86% yield.

Keywords

3,5-bis(1H-pyrrol-2-yl)-4H-1,2,4-triazol-4-amines hydrazine hydrate 1H-pyrrole-2-carbo-nitriles 

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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • T. E. Glotova
    • 1
  • D. A. Shabalin
    • 1
  • M. Yu. Dvorko
    • 1
  • I. A. Ushakov
    • 1
  • E. Yu. Schmidt
    • 1
  • A. V. Ivanov
    • 1
  • A. I. Mikhaleva
    • 1
  • B. A. Trofimov
    • 1
  1. 1.A. E. Favorsky Irkutsk Institute of ChemistrySiberian Branch of the Russian Academy of SciencesIrkutskRussia

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