Novel synthesis of 2-trichloromethyl-4-vinyloxazoline and its derivatization by ring cleavage reactions*
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A novel efficient and eco-friendly method for the synthesis of 2-trichloromethyl-4-vinyloxazoline is presented that involves Lewis acid-catalyzed cyclization of bisimidate derived from but-3-ene-1,2-diol. The derivatization potential of 2-trichloromethyl-4-vinyloxazoline is demonstrated by ring opening reactions with water, hydrobromic acid, hydrochloric acid, and acetic acid leading to allylamine derivatives.
Keywordsallyl amine Lewis acids oxazoline trichloroacetimidate cyclization
This work was carried out with the financial support of the European Social Fund (No. 2009/0203/1DP/184.108.40.206/09/APIA/VIAA/023).
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