Chemistry of Heterocyclic Compounds

, Volume 48, Issue 5, pp 773–784 | Cite as

Synthesis of imidazo[4,5-b]pyridines with a chiral substituent at the nitrogen atom and their conversion to piperazine derivatives

  • K. V. Bukhryakov
  • A. V. Kurkin
  • M. A. Yurovskaya
Article
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Imidazopyridine and benzimidazole derivatives have been prepared with chiral substituents at the nitrogen atom and have been converted to the corresponding condensed structures fused with a piperazine ring. A method has been developed for the synthesis of novel class of compounds – 6,7,8,9-tetra-hydropyrido[3',2':4,5]imidazo[1,2-a]pyrazine derivatives.

Keywords

tert-butyl imidazo[4,5-b]pyridine-2-carboxylate 2-chloro-3-nitropyridine chiral substituent at a nitrogen atom nucleophilic substitution optically active amino acid esters 
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Copyright information

© Springer Science+Business Media, Inc. 2012

Authors and Affiliations

  • K. V. Bukhryakov
    • 1
  • A. V. Kurkin
    • 1
  • M. A. Yurovskaya
    • 1
  1. 1.M. V. Lomonosov State UniversityMoscowRussia

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