One-pot chemoselective synthesis of novel fused pyrimidine derivatives

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One-pot triple-component reaction of 4-hydroxycoumarin with aromatic aldehydes and 2-aminobenzimidazole, 3-amino-1H-1,2,4-triazole, or 6-aminouracil in acetonitrile in the presence of catalytic amounts of sulfamic acid led to a chemoselective synthesis of chromeno[4,3-d]pyrimidine-6-one, triazolo[1,5-a]pyrimidin-5-one, and pyrido[2,3-d]-pyrimidine-2,4,7-trione derivatives, respectively, in good yields.

Keywords

chromeno[4,3-d]pyrimidinones pyrido[2,3-d]pyrimidine-2,4,7-triones pyrimidine derivatives sulfamic acid triazolo[1,5-a]pyrimidin-5-ones multicomponent reaction 
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Notes

We gratefully acknowledge partial financial support from the Alzahra University Research Council.

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Copyright information

© Springer Science+Business Media, Inc. 2011

Authors and Affiliations

  1. 1.Department of Chemistry, School of SciencesAlzahra UniversityTehranIran

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