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Chemistry of Heterocyclic Compounds

, Volume 44, Issue 2, pp 208–213 | Cite as

Condensed isoquinolines 27*. Synthesis and oxidation reactions of 5,13-dihydro-11H-isoquino[3,2-b]quinazolin-11-one

  • L. M. PotikhaEmail author
  • R. M. Gutsul
  • A. V. Turov
  • V. A. Kovtunenko
Article

Abstract

Condensation of 2-(cyanomethyl)benzoic acid with 2-aminobenzylamine gave 6,11-dihydro-13H-isoquino[3,2-b]quinazolin-11-one. Its oxidation in nitrobenzene led to the formation of 5,13,5′,13′-hexahydro[6,6′]bi[isoquino[3,2-b]quinazoline]-11,11′-dione, but in dichlorobenzene in the presence of elemental sulfur and iodine it gave the rearrangement product 6H-dibenzo[b,f][1,8]naphthyridin-5-one.

Keywords

2-aminobenzylamine [6,6′]bi[isoquino[3,2-b]quinazoline] dibenzo[b,f][1,8]naphthyridine isoquino[3,2-b]quinazoline 2-(cyanomethyl)benzoic acid oxidation rearrangement 

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Copyright information

© Springer Science+Business Media, Inc. 2008

Authors and Affiliations

  • L. M. Potikha
    • 1
    Email author
  • R. M. Gutsul
    • 1
  • A. V. Turov
    • 1
  • V. A. Kovtunenko
    • 1
  1. 1.Taras Shevchenko Kiev National UniversityKievUkraine

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