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Chemistry of Heterocyclic Compounds

, Volume 42, Issue 7, pp 948–954 | Cite as

Heterophase N-aminomethylation of 5-arylidenepseudothiohydantoins by arylamines and aqueous formaldehyde in aromatic solvents: Effect of substituents in the heterocyclic substrate and the aryl amine on the efficiency of the process

  • S. M. Ramsh
  • N. L. Medvedskiy
  • S. O. Uryupov
Article

Abstract

We have obtained a series of 3-aryl-7-arylidene-3,4-dihydro-2H-[1,3]thiazolo[3,2-a][1,3,5]triazin-6(7H)-ones by means of heterophase aminomethylation of 2-amino-5-arylidene-1,3-thiazol-4(5H)-ones with aqueous formaldehyde and aromatic amines in benzene or toluene. We explain the effect of substituents in the heterocyclic substrate and the aryl amine on the efficiency of the process within a detailed scheme for one of the possible aminomethylation reaction routes.

Keywords

2-amino-5-arylidene-1,3-thiazol-4(5H)-ones (5-arylidenepseudothiohydantoins) 3-aryl-7-arylidene-3,4-dihydro-2H-[1,3]thiazolo[3,2-a][1,3,5]triazin-6(7H)-ones aminomethylation synthesis 

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Copyright information

© Springer Science+Business Media, Inc. 2006

Authors and Affiliations

  • S. M. Ramsh
    • 1
  • N. L. Medvedskiy
    • 1
  • S. O. Uryupov
    • 1
  1. 1.St. Petersburg State Technical UniversitySt. PetersburgRussia

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