Correlated pedigree and molecular estimates of inbreeding and their ability to detect inbreeding depression in the Icelandic sheepdog, a recently bottlenecked population of domestic dogs
- 585 Downloads
We examine the relationship of the inbreeding coefficient (f) and molecular estimates of inbreeding (IR, sMLH) in the Icelandic sheepdog. The breed experienced a severe genetic bottleneck and near extinction in the last century. Molecular estimates and the inbreeding coefficient are significantly correlated despite the moderate number of markers and individuals used in this study. This is most likely an effect of the extreme relatedness and relatively high variance in individual inbreeding coefficients in the population. There is a significant relationship between inbreeding (f) and the occurrence of hip dysplasia. However, the molecular measures did not detect hip dysplasia as an inbreeding effect.
KeywordsInbreeding Multilocus heterozygosity Heterozygosity fitness correlations Canis familiaris
We would like to thank the Icelandic sheepdog unit at the Icelandic Kennel Club for providing pedigree data, hip dysplasia records and assisting with DNA sampling. Thanks to Prokaria ehf for help with laboratory work. This work was supported by the Icelandic Council for Genetic Resources in Agriculture.
- Belkhir K (2000) GENETIX 4.0. Laboatoire génome, populations, interactions. CNRS UPR 9060, Monpellier, FranceGoogle Scholar
- Frankham R, Ballou JD, Briscoe DA (2002) Introduction to conservation genetics. Cambridge University Press, Cambridge, UKGoogle Scholar
- Mäki K, Groen AF, Liinamo AE, Ojala M (2001) Population structure, inbreeding trend and their association with hip and elbow dysplasia in dogs. Anim Sci 73:217–228Google Scholar