Clinical & Experimental Metastasis

, Volume 35, Issue 3, pp 167–217 | Cite as

Abstracts from the 11th International Symposium on Minimal Residual Disease, 3–5 May 2018, Montpellier, France

  • Catherine Alix-Panabières
  • Klaus Pantel

Keynote introductory lecture

Liquid biopsy: biology and clinical applications

The analysis of circulating tumor cells (CTCs) in blood may provide clinically relevant information as “liquid biopsy” (Alix-Panabieres & Pantel, Nature Rev Cancer 2014) and provide new insights into tumor biology (Lu et al., Cancer Cell, 2011; LeBleu et al., Nat. Cell Biol., 2014; Mueller et al., Science TM, 2014; Werner et al., Cancer Discovery, 2015). Besides CTCs the molecular analysis of ctDNA provides important complementary information as “liquid biopsy” (Pantel & Alix-Panabieres, Cancer Res., 2013; Pantel et al., Nature Med. 2013; Heitzer et al., Genome Med. 2013; Schwarzenbach et al., Nature Rev. Clin. Oncol., 2014, Joosse & Pantel, Cancer Cell 2015; Bardelli & Pantel, Cancer Cell 2017). Moreover, circulating microRNAs, extracellular vesicles and tumor-educated platelets are also interesting new members of the “Liquid Biopsy family” with potential clinical relevance in the future. Recently, exosomes...

Copyright information

© Springer Nature B.V. 2018

Authors and Affiliations

  • Catherine Alix-Panabières
    • 1
  • Klaus Pantel
    • 2
  1. 1.Laboratory of Rare Human Circulating CellsUniversity Medical Centre of Montpellier, University of MontpellierMontpellierFrance
  2. 2.Department of Tumor BiologyUniversity Medical Centre Hamburg-EppendorfHamburgGermany

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