Proffered abstracts from the 17th Biennial Congress of the Metastasis Research Society
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1–5 August 2018, Princeton, USA
Note: Some abstracts have not been published at the request of the authors.
POSTER SESSION I (NON-TRAINEES)
Colorectal cancer associated Natural Killer cells are endowed by pro-metastatic and proangiogenic phenotype/functions by upregulating the MMP9-TIMP2 and Angiogenin axis
Antonino Bruno, Barbara Bassani, Giuseppe Pelosi, Luigi Boni, Lorenzo Dominioni, Lorenzo Mortara, Douglas M. Noonan, Adriana Albini
Natural Killer (NK) cells are effector lymphocytes involved in tumor immunosurveillance. In solid malignancies, tumor associated (TANK; peripheral blood) and tumor infiltrating (TINK) NK cells acquire altered phenotype and functions. In previous studies, we reported that NK cells from non-small cell lung cancer can acquire a decidual-like CD56brightCD16-VEGFhighPlGFhighIL-8 + low phenotype and functionally and molecularly characterize the TINK and TANKs from blood and tissue samples of colorectal cancer (CRC) patients, compared to NK isolated from...