Clinical & Experimental Metastasis

, Volume 26, Issue 6, pp 559–567

Multi-faceted role of HSP40 in cancer

  • Aparna Mitra
  • Lalita A. Shevde
  • Rajeev S. Samant


HSP40 (DNAJ) is an understudied family of co-chaperones. The human genome codes for over 41 members of HSP40 family that reside at distinct intracellular locations. Despite their large numbers, little is known about their physiologic roles. Recent research has revealed involvement of some of the DNAJ family members in various types of cancers. In this article we summarize the information about the involvement of human DNAJ family members in various aspects of cancer biology. Furthermore we discuss the potential role of the J domain of DNAJ proteins in cancer biology.


HSP40 DnaJ Cancer 


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Copyright information

© Springer Science+Business Media B.V. 2009

Authors and Affiliations

  • Aparna Mitra
    • 1
  • Lalita A. Shevde
    • 1
  • Rajeev S. Samant
    • 1
  1. 1.Department of Oncologic Sciences, Mitchell Cancer InstituteUniversity of South AlabamaMobileUSA

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